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Related Concept Videos

The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...

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Related Experiment Video

Updated: Jul 2, 2026

Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse Oocytes
10:09

Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse Oocytes

Published on: September 13, 2022

The spindle checkpoint and chromosomal stability.

W Qi1, H Yu

  • 1Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Tex., USA.

Genome Dynamics
|August 30, 2008
PubMed
Summary
This summary is machine-generated.

Chromosome missegregation causes aneuploidy, a hallmark of cancer. This review explores how spindle checkpoint malfunctions contribute to aneuploidy and tumor formation.

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Last Updated: Jul 2, 2026

Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse Oocytes
10:09

Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse Oocytes

Published on: September 13, 2022

Live Cell Imaging of Chromosome Segregation During Mitosis
06:39

Live Cell Imaging of Chromosome Segregation During Mitosis

Published on: March 14, 2018

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Area of Science:

  • Genetics
  • Cell Biology
  • Cancer Research

Background:

  • Normal human somatic cells possess 46 chromosomes.
  • Chromosome missegregation results in aneuploidy, altering gene dosage and potentially causing disease.
  • Aneuploidy is prevalent in human cancers and is thought to contribute to tumorigenesis.

Purpose of the Study:

  • To review the molecular mechanisms of the spindle checkpoint.
  • To examine the link between spindle checkpoint dysfunction, aneuploidy, and cancer development.

Main Methods:

  • Literature review of current research on the spindle checkpoint.
  • Analysis of evidence connecting spindle checkpoint malfunction to aneuploidy and tumorigenesis.

Main Results:

  • The spindle checkpoint is a critical surveillance mechanism for accurate chromosome segregation.
  • Evidence suggests that defects in the spindle checkpoint can lead to aneuploidy.
  • Spindle checkpoint malfunction is increasingly implicated in the development of cancer.

Conclusions:

  • The spindle checkpoint plays a vital role in preventing aneuploidy.
  • Dysfunctional spindle checkpoints are a significant factor in cancer formation.
  • Further research into the spindle checkpoint may offer therapeutic targets for cancer treatment.