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Updated: Jul 2, 2026

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel Film
Published on: December 13, 2024
Topical fusidic acid for treatment of Clostridium perfringens Keratitis
Isabel Mayo1, Francesc Puchades, Maria Fideliz de la Paz
1Department of Ophthalmology, Hospital La Fe, Valencia, Spain.
Purpose:
To report the therapeutic outcome of primary corneal infection by Clostridium perfringens.
Methods:
A 65-year-old cleaning lady had pain, decreased visual acuity, redness, and photophobia in her left eye for 4 days. A paracentral corneal ulcer with subepithelial bullae and several frothy bubbles in the ulcer bed was found. Two different cultures were positive for C. perfringens.
Results:
Treatment with topical fusidic acid 1% was given, and the corneal infiltrate regressed within 6 weeks to a faint corneal opacity.
Conclusions:
Clostridium perfringens keratitis can be treated successfully with topical fusidic acid.
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