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Updated: Jul 2, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Parathyroidectomy followed by kidney transplantation can improve bone mineral density in patients with secondary
Fong-Fu Chou1, Kun-Chou Hsieh, Yen-Ta Chen
1Department of Surgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Niao-Sung Hsiang, Kaohsiung Hsien, Taiwan.
Background:
We studied bone mineral density (BMD) after total parathyroidectomy plus autotransplantation (TPTD plus AT) followed by kidney transplantation in patients with symptomatic secondary hyperparathyroidism.
Methods:
We recruited 43 patients who were operated on with TPTD plus AT for this study. Group A (n=36) patients continued hemodialysis regularly thereafter; Group B (n=7) patients were followed by cadaveric kidney transplantation. In group A, serum calcium, phosphorus, alkaline phosphatase (Alk-ptase) and intact parathyroid hormone (iPTH) levels were measured at baseline, 1 week, and in the late follow-up period. In group B, serum calcium, phosphorus, Alk-ptase and iPTH levels were measured at baseline, 1 week after parathyroidectomy, and in the late follow-up period after kidney transplantation. The BMD of lumbar spine, femur, ulna and radius was measured with dual x-ray absorptiometry at baseline, and again at 1 year in group A and at 1 year after kidney transplantation in group B.
Results:
At 1 week after TPTD plus AT, calcium, phosphorus, and iPTH levels decreased significantly but Alk-ptase did not. In the late follow up period calcium, phosphorus, Alk-ptase and iPTH levels decreased significantly compared with those at baseline. In group A, the BMD of lumbar spine, femur, ulna and radius increased significantly 1 year later. In group B, the BMD of femur, ulna and radius increased significantly 1 year after kidney transplantation, but the BMD of lumbar spine did not.
Conclusion:
TPTD plus AT followed by kidney transplantation performed for symptomatic secondary hyperparathyroidism can improve the BMD of femur, ulna, and radius.
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