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Related Experiment Video

Updated: Jul 2, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Multiple hybrid granular cell tumor-perineuriomas.

Alireza Zarineh1, Melanie E Costa, Michael S Rabkin

  • 1Department of Pathology and Laboratory Medicine, Allegheny General Hospital, Pittsburgh, PA 15212, USA. azarineh@wpahs.org

The American Journal of Surgical Pathology
|August 30, 2008
PubMed
Summary

This study describes a rare case of multiple hybrid granular cell tumors and perineuriomas, a novel combination of peripheral nerve sheath tumors. The findings suggest a potential Schwannian origin for both cell types, offering new insights into tumor pathogenesis.

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Area of Science:

  • Oncology
  • Pathology
  • Dermatology

Background:

  • Peripheral nerve sheath tumors (PNSTs) are neoplasms arising from nerve structures.
  • Hybrid PNSTs, combining features of different nerve sheath tumors, are rare.
  • Perineuriomas and granular cell tumors are distinct types of PNSTs.

Observation:

  • A 47-year-old man presented with over 20 cutaneous nodules on his extremities since childhood.
  • Histological examination revealed tumors with features of both perineurioma and granular cell tumor.
  • Immunohistochemistry showed distinct cell populations with specific markers (EMA, S-100, NK1/C3, CD68).

Findings:

  • The tumors were composed of bland spindle cells (EMA-positive, S-100 negative) and granular cells (S-100, NK1/C3, CD68 positive).

Related Experiment Videos

Last Updated: Jul 2, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

  • Areas resembling pure granular cell tumor were present within the hybrid lesions.
  • This case represents the first reported instance of multiple hybrid granular cell tumor-perineurioma.

    • Implications:

    • The findings suggest a possible common Schwannian progenitor cell for both perineurial and granular cell components.
    • This case expands the understanding of PNST diversity and hybrid tumor formation.
    • Further research into the pathogenesis of hybrid PNSTs is warranted.