Bone marrow and stem cell transplantation: Malaysian experience

Area of Science:

• Hematology
• Transplant Immunology
• Public Health

Background:

• The first bone marrow transplant (BMT) in Malaysia occurred in 1987.
• Over 1155 transplantations have been performed across eight centers.
• Allogeneic transplants, primarily from HLA-identical siblings, are most common.

Purpose of the Study:

• To review the history and outcomes of bone marrow transplantation in Malaysia.
• To analyze patient demographics, indications, and survival rates.
• To inform future developments in Malaysia's transplant programs.

Main Methods:

• Retrospective analysis of 1155 bone marrow transplantations.
• Data collection from eight Malaysian transplant centers.
• Survival analysis for allogeneic and autologous transplantations.

Main Results:

• The mean patient age was 26 years, with hematological malignancies as the primary indication.
• Overall survival rates were 60% for allogeneic and 52% for autologous transplants.
• Mortality was mainly due to the underlying disease and infection.

Conclusions:

• Malaysia has established a significant bone marrow transplant program since 1987.
• Survival rates are comparable to international standards, with ongoing efforts to expand resources.
• Further development of cord blood banks and donor registries is underway.