Hematopoietic stem cell transplantation in Oman.

Area of Science:

• Hematology
• Transplantation Medicine
• Public Health

Background:

• Hematopoietic stem cell transplantation (HSCT) is a critical treatment for hematologic disorders.
• Sultan Qaboos University (SQU) hospital in Oman established the country's sole HSCT program in 1995.
• The program has provided HSCT services for over a decade, serving a population of 2.3 million.

Purpose of the Study:

• To review the outcomes and scope of the HSCT program at Sultan Qaboos University hospital.
• To analyze transplant indications, patient demographics, and transplant types performed.
• To provide insights into the development and future expansion of HSCT services in Oman.

Main Methods:

• Retrospective analysis of HSCT patient data.
• Data collection from June 1995 to August 2006.
• Review of patient demographics, transplant indications, and transplant types.

Main Results:

• A total of 128 HSCT procedures were performed between 1995 and 2006, averaging 10-12 per year.
• Hematologic malignancies (49%) and inherited disorders (42%) were the primary indications for HSCT.
• HLA-matched sibling-donor allogeneic HSCTs constituted the majority of transplants, with homozygous beta-thalassemia and primary immunodeficiency as key inherited disorder indications.

Conclusions:

• The HSCT program at SQU hospital has successfully provided essential treatment for complex hematologic conditions in Oman.
• The program's success has led to the development of a larger facility to meet growing patient needs.
• Continued development of HSCT services is crucial for improving patient outcomes in the region.