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Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)
Published on: February 25, 2007
Hematopoietic stem cell transplantation in Thailand
1Division of Hematology, Department of Medicine, Chulabhorn BMT Center, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Bone Marrow Transplantation
|September 25, 2008
Summary
Hematopoietic stem cell transplantation (HSCT) in Thailand shows results comparable to Western countries. High costs limit patient access, and while acute graft-versus-host disease (GVHD) is low, chronic GVHD is prevalent, particularly with peripheral blood stem cells (PBSC).
Area of Science:
- Hematology
- Transplantation Medicine
- Clinical Research
Background:
- Hematopoietic stem cell transplantation (HSCT) was initiated in Thailand in 1986.
- Currently, four major hospitals are active centers for HSCT.
- The annual volume of HSCT procedures ranges from 120 to 150 cases.
Purpose of the Study:
- To review the current status and outcomes of HSCT in Thailand.
- To compare Thai HSCT results with international data.
- To identify challenges and specific complications in the Thai HSCT context.
Main Methods:
- Retrospective analysis of HSCT procedures performed in Thailand.
- Data collection on transplant volume, patient eligibility, and outcomes.
- Analysis of graft-versus-host disease (GVHD) incidence, differentiating acute and chronic forms.
Main Results:
- Overall HSCT outcomes in Thailand are comparable to those reported in Western countries.
- The incidence of acute graft-versus-host disease (GVHD) is low.
- The incidence of chronic GVHD is high, particularly in patients receiving peripheral blood stem cells (PBSC).
Conclusions:
- HSCT in Thailand has achieved international standards in terms of overall results.
- High procedure costs represent a significant barrier to patient access.
- Strategies to mitigate chronic GVHD, especially in PBSC transplant recipients, may be warranted.
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