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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Current status of blood and marrow transplantation for patients with AML.

Bone marrow transplantation·2008
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Using Cleavage Under Targets and Tagmentation (CUT&Tag) Assay in Mouse Myoblast Research
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Stem cells: the challenge and opportunities.

Ha Messner1

  • 1Department of Medical Oncology/Hematology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada. hans.messner@uhn.on.ca

Bone Marrow Transplantation
|September 25, 2008
PubMed
Summary
This summary is machine-generated.

Hematopoietic stem cells (HSCs) age, leading to increased myeloid leukemia gene expression and myeloproliferative disorders. Primitive cells may regenerate other organs, potentially reducing the need for organ transplantation.

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Area of Science:

  • Hematology
  • Stem Cell Biology
  • Aging Research

Background:

  • Hematopoietic stem cells (HSCs) exhibit hierarchical organization with long-term repopulating HSCs (LT-HSCs).
  • LT-HSCs undergo aging, impacting their self-renewal and differentiation.
  • Marrow cells demonstrate broader migratory and regenerative potential than previously assumed.

Purpose of the Study:

  • To elucidate the aging process of LT-HSCs and its implications.
  • To explore the potential of primitive cells in organ regeneration.
  • To investigate novel therapeutic strategies for organ repair.

Main Methods:

  • Analysis of HSC hierarchy and function.
  • Investigation of age-related changes in stem cell populations.
  • Exploration of cell migration and tissue regeneration capabilities.

Main Results:

  • Aging HSCs show increased self-renewal and myeloid gene expression, correlating with myeloproliferative disorders.
  • Primitive cells can circulate and contribute to regeneration in various organs.
  • Potential for cell-based therapies to repair damaged organs is suggested.

Conclusions:

  • Stem cell aging contributes to age-related hematological malignancies.
  • Marrow-derived cells possess regenerative potential beyond the hematopoietic system.
  • Cell and cytokine therapies may offer alternatives to organ transplantation for damaged organs.