Jove
Visualize
Contact Us

Related Concept Videos

Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Height-based formulas for predicting intravascular length of tunnelled neck central venous catheter in paediatric population.

Pediatric surgery international·2023
Same author

Cognitive problems following hematopoietic stem cell transplant: relationships with sleep, depression and fatigue.

Bone marrow transplantation·2016
Same author

An exploration of the applicability of the refined disease risk index and its integration with other independent risk factors for individualized prognostication.

Bone marrow transplantation·2016
Same author

Allogeneic haematopoietic SCT for natural killer/T-cell lymphoma: a multicentre analysis from the Asia Lymphoma Study Group.

Bone marrow transplantation·2014
Same author

Early post transplant (F-18) 2-fluoro-2-deoxyglucose positron emission tomography does not predict outcome for patients undergoing auto-SCT in non-Hodgkin and Hodgkin lymphoma.

Bone marrow transplantation·2010
Same author

Successful intensive chemotherapy followed by autologous hematopoietic cell transplantation in a patient with acute myeloid leukemia and hepatosplenic candidiasis: case report and review of literature.

Transplant infectious disease : an official journal of the Transplantation Society·2009
Same journal

ALLOPLUS: allogeneic hematopoietic stem cell transplantation in children and adult people living with human immunodeficiency virus, a retrospective study of the SFGM-TC.

Bone marrow transplantation·2026
Same journal

Epigenetic priming with azacitidine-BEAM versus decitabine-BEAM conditioning for autologous transplantation in non-Hodgkin's lymphoma.

Bone marrow transplantation·2026
Same journal

CHIME: a novel HLA eplet model associates with non-relapse mortality in haploidentical hematopoietic cell transplant with post-transplant cyclophosphamide.

Bone marrow transplantation·2026
Same journal

Transplant outcomes for patients with severe acquired aplastic anemia over the age of 40 using busulfan, fludarabine, reduced-dose cyclophosphamide, and anti-thymocyte globulin conditioning regimen.

Bone marrow transplantation·2026
Same journal

A holistic prognostic model for leukemia-free survival after allogeneic transplantation in acute leukemia.

Bone marrow transplantation·2026
Same journal

Early software-assisted response predicts survival in a prospective cohort of 258 newly diagnosed cGvHD patients.

Bone marrow transplantation·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 2, 2026

Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)
20:38

Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)

Published on: February 25, 2007

Haploidentical hematopoietic cell transplantation.

L-P Koh1, N Chao

  • 1Duke University, Durham, NC 27705-3976, USA.

Bone Marrow Transplantation
|September 25, 2008
PubMed
Summary
This summary is machine-generated.

Haploidentical hematopoietic stem cell transplantation (HSCT) offers a vital alternative when matched donors are unavailable. Advances have improved outcomes, but challenges in immune reconstitution and preventing infections persist.

More Related Videos

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
11:55

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Published on: March 14, 2011

Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition
09:00

Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition

Published on: June 16, 2019

Related Experiment Videos

Last Updated: Jul 2, 2026

Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)
20:38

Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)

Published on: February 25, 2007

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
11:55

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Published on: March 14, 2011

Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition
09:00

Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition

Published on: June 16, 2019

Area of Science:

  • Hematology
  • Immunology
  • Transplantation Medicine

Background:

  • Haploidentical hematopoietic stem cell transplantation (HSCT) expands donor options for patients lacking HLA-matched siblings.
  • Early HSCT attempts faced high treatment-related morbidity and mortality due to graft-versus-host disease (GVHD) and infections.
  • Recent advancements have significantly reduced early transplant complications, improving engraftment and therapeutic benefits.

Purpose of the Study:

  • To review the evolution and current status of haploidentical HSCT.
  • To identify persistent challenges in immune reconstitution and post-transplant complications.
  • To explore novel strategies for enhancing efficacy and safety in haploidentical HSCT.

Main Methods:

  • Review of recent literature and clinical advancements in haploidentical HSCT.
  • Analysis of strategies including T-cell depletion, megadoses of stem cells, and reduced-intensity conditioning.
  • Exploration of emerging approaches like adoptive cellular immunity and selective allodepletion.

Main Results:

  • Significant reductions in early transplant-related mortality and GVHD have been achieved through modern techniques.
  • Robust engraftment and enhanced therapeutic benefits are now more attainable with haploidentical HSCT.
  • Delayed immune reconstitution remains a critical issue, leading to infections and limiting transplant efficacy.

Conclusions:

  • Haploidentical HSCT is a viable option, but challenges in immune reconstitution and infection prevention persist.
  • Adoptive cellular immunity and selective allodepletion show promise for rapid immune reconstitution without GVHD.
  • Future research should focus on optimizing safety, preserving graft-versus-leukemia (GVL) activity, and ensuring prompt immune recovery.