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Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
Published on: March 17, 2023
Computer screen photo-excited surface plasmon resonance imaging
Daniel Filippini1, Fredrik Winquist, Ingemar Lundström
1Division of Applied Physics, IFM - Linköping University, Linköping 58183, Sweden. danfi@ifm.liu.se
Analytica Chimica Acta
|August 30, 2008
Summary
Researchers developed a novel surface plasmon resonance (SPR) imaging technique using a computer screen and webcam. This cost-effective method enables detailed analysis of thin films and protein deposits.
Area of Science:
- Nanotechnology
- Optical Physics
- Biomedical Sensing
Background:
- Surface Plasmon Resonance (SPR) is a powerful optical sensing technique.
- Traditional SPR setups often require specialized and expensive equipment.
- Developing accessible SPR imaging methods is crucial for broader scientific application.
Purpose of the Study:
- To demonstrate angle and spectra resolved SPR imaging using common consumer electronics.
- To analyze gold and silver thin films with protein deposits.
- To establish a cost-effective and accessible SPR sensing platform.
Main Methods:
- Utilized a computer screen as a multi-angle, p-polarized light source.
- Employed a webcam as a detector for SPR imaging.
- Developed a reflectance model accounting for source and detector characteristics in a Kretchmann configuration.
Main Results:
- Successfully generated angle and spectra resolved SPR images of thin films.
- Observed distinctive SPR landscapes indicative of protein deposits.
- Achieved high sensitivity and resolution (e.g., 6.014x10(-4) RIU).
Conclusions:
- This proof-of-concept demonstrates the feasibility of using ubiquitous instrumentation for advanced SPR analysis.
- The developed method offers a low-cost alternative for SPR imaging.
- The technique shows promise for various applications in sensing and material analysis.
