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Related Experiment Video

Updated: Jul 2, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

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Published on: August 4, 2022

Interleukin-23: immunological roles and clinical implications.

Zi Yan Tan¹, Kenneth W Bealgey, Yong Fang

¹The Third People's Hospital, The School of Medicine, Shanghai JiaoTong University, Shanghai, China.

The International Journal of Biochemistry & Cell Biology

|August 30, 2008

Summary

Interleukin-23 (IL-23) links innate and adaptive immunity, driving T cell responses in inflammatory diseases. Targeting IL-23 offers potential therapeutic strategies for conditions like IBD and rheumatoid arthritis.

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Area of Science:

Immunology
Molecular Biology
Cell Biology

Background:

Interleukin-23 (IL-23) is structurally and immunologically similar to IL-12.
IL-23 is produced by activated type 1 macrophages and dendritic cells (DCs).
IL-23 plays a critical role in T cell differentiation and memory expansion.

Purpose of the Study:

To review the immunological functions of IL-23.
To explore therapeutic targets for IL-23 in inflammatory diseases.

Main Methods:

Literature review of immunological studies on IL-23.
Analysis of IL-23's role in T cell responses and inflammatory conditions.

Main Results:

IL-23 induces strong Th1 and Th17 immune responses.
IL-23 is implicated in inflammatory diseases including rheumatoid arthritis, IBD, and gastritis.
Polymorphisms in the IL-23 receptor complex are linked to chronic inflammatory diseases.

Conclusions:

IL-23 is a key mediator linking innate and adaptive immunity.
Understanding IL-23's role is crucial for developing novel therapies for inflammatory disorders.