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Updated: Jul 2, 2026

06:51
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
In vitro activity of OPT-80 tested against clinical isolates of toxin-producing Clostridium difficile
James A Karlowsky1, Nancy M Laing, George G Zhanel
1Department of Clinical Microbiology, Health Sciences Centre, MS673C, 820 Sherbrook Street, Winnipeg, Manitoba, Canada. jkarlowsky@hsc.mb.ca
Antimicrobial Agents and Chemotherapy
|August 30, 2008
Abstract:
Agar dilution antimicrobial susceptibility testing (CLSI, M11-A7, 2007) performed for 208 toxin-producing clinical isolates of Clostridium difficile resulted in OPT-80 MICs ranging from 0.06 to 1 microg/ml, with 90% of the isolates inhibited by a concentration of 0.5 microg/ml. The in vitro activity of OPT-80 was independent of the susceptibilities of isolates to nine other antimicrobial agents.
