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Hypercalcaemia due to calcium binding by a polymeric IgA kappa-paraprotein
1University Department of Chemical Pathology, Royal Liverpool Hospital, UK.
Annals of Clinical Biochemistry
|May 1, 1991
Summary
This study investigated elevated total serum calcium in a multiple myeloma patient. The abnormal immunoglobulin (IgA kappa-paraprotein) directly bound calcium, causing high levels without hypercalcemia symptoms.
Area of Science:
- Clinical Biochemistry
- Immunology
- Oncology
Background:
- Multiple myeloma is a plasma cell malignancy often associated with complications.
- Elevated total serum calcium (hypercalcemia) is a known complication, but can be asymptomatic.
- The role of paraproteins in calcium dysregulation requires further elucidation.