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Fructosamine in diabetes screening of the elderly
S C Croxson1, S Absalom, A C Burden
1Leicester General Hospital, UK.
Annals of Clinical Biochemistry
|May 1, 1991
Summary
Serum fructosamine is a useful diabetes screening tool for older adults. This test identified new diabetes cases in a survey, suggesting its potential for early detection in elderly populations.
Area of Science:
- Gerontology
- Endocrinology
- Clinical Chemistry
Background:
- Diabetes mellitus is a significant health concern, particularly in aging populations.
- Early detection and management are crucial for preventing long-term complications.
- Serum fructosamine offers a potential biomarker for assessing glycemic control.
Purpose of the Study:
- To evaluate the efficacy of serum fructosamine as a screening tool for diabetes detection.
- To assess the prevalence of newly diagnosed diabetes in an elderly population using a modified oral glucose tolerance test (MOGTT).
Main Methods:
- A diabetes survey involving 742 residents aged 65-85 years in Melton Mowbray.
- Modified oral glucose tolerance test (MOGTT) administered under standardized morning resting conditions.
- Serum fructosamine levels measured in a subgroup of normal subjects and compared with MOGTT results.
Main Results:
- Twenty-five new cases of diabetes were identified through the MOGTT.
- Of the 23 new diabetics with measured fructosamine, 17 had levels above the 95th percentile and four above the 90th percentile.
- Serum fructosamine concentration showed a Gaussian distribution in normal subjects (mean = 1.67 mmol/L, SD = 0.126 mmol/L).
Conclusions:
- Serum fructosamine serves as a valuable screening method for identifying potential diabetes cases.
- The effectiveness of fructosamine screening may be influenced by standardized sampling procedures and the specific population studied.
- This study supports the utility of serum fructosamine in detecting diabetes within an elderly demographic.