Related Experiment Video
Updated: Jul 2, 2026
Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
The impact of histopathologic diagnosis on the proper management of testis neoplasms
Giovanni Ponti1, Maurilio Ponzoni, Andrés Jm Ferreri
1Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
Background:
A 45-year-old man underwent a right orchiectomy for a rapidly growing testicular mass. After histologic and imaging examinations the patient was diagnosed with stage I (T1N0M0) seminoma. Approximately 2 months after surgery the patient began to complain of abdominal pain and a CT scan revealed a bulky retroperitoneal mass. The patient did not receive the planned prophylactic radiotherapy and was treated with combined cisplatin, etoposide and bleomycin chemotherapy; after the completion of this treatment he achieved complete remission. Three years later, and while still undergoing follow-up, the patient developed multiple neurological motor deficits.
Investigations:
Brain MRI and CT-guided biopsy.
Diagnosis:
Diffuse large B-cell lymphoma of the testis, relapsing in the central nervous system.
Management:
High-dose methotrexate alone or in combination with high-dose cytarabine.
Related Concept Videos
01:27Testes: Histology
The spermatogenic cells, responsible for producing sperm, are...
01:20Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...