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Related Concept Videos

Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Structure of Cadherins01:25

Structure of Cadherins

The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This diversity of cadherins...
Adherens Junctions01:24

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...

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Updated: Jul 2, 2026

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

The cell-cell adhesion molecule E-cadherin.

F van Roy1, G Berx

  • 1Department for Molecular Biomedical Research, Molecular Cell Biology Unit, VIB, Technologiepark 927, 9052 Ghent, Belgium. F.Vanroy@dmbr.UGent.be

Cellular and Molecular Life Sciences : CMLS
|August 30, 2008
PubMed
Summary
This summary is machine-generated.

E-cadherin is a key cell adhesion molecule vital for tissue formation and cancer suppression. Its structure, function, and disruption in cancer are reviewed, highlighting its roles in development and disease.

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Last Updated: Jul 2, 2026

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

Human Neutrophil Flow Chamber Adhesion Assay
12:42

Human Neutrophil Flow Chamber Adhesion Assay

Published on: July 2, 2014

Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads
07:55

Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads

Published on: March 8, 2017

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • E-cadherin is a crucial calcium-dependent cell-cell adhesion molecule.
  • It belongs to the cadherin superfamily and plays significant roles in epithelial cell behavior.
  • E-cadherin is fundamental in tissue formation and acts as a tumor suppressor.

Purpose of the Study:

  • To provide a comprehensive review of E-cadherin.
  • To summarize its structure, gene regulation, and protein processing.
  • To discuss its diverse functions, including cell adhesion, signaling, and roles in development and cancer.

Main Methods:

  • Literature review and synthesis of existing research on E-cadherin.
  • Analysis of E-cadherin structure, gene, and protein interactions.
  • Compilation of data on E-cadherin's role in embryonic development and disease models.

Main Results:

  • Detailed overview of E-cadherin gene and transcript regulation.
  • Presentation of models for E-cadherin-catenin complexes and cell junctions.
  • Discussion of E-cadherin's homophilic and heterophilic adhesion, pathogen receptor role, and signaling activities.
  • Exploration of E-cadherin's function in embryonic development and morphogenesis across various animal models.

Conclusions:

  • E-cadherin's intricate structure underlies its diverse functions in cell adhesion and tissue integrity.
  • Disruption of E-cadherin function through mutations, epigenetic changes, or altered processing is a hallmark of cancer.
  • Understanding E-cadherin is critical for insights into development, morphogenesis, and cancer biology.