Related Experiment Video
Updated: Jul 2, 2026
![Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[18F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F67458.jpg&w=3840&q=50)
Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[18F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level
Published on: January 24, 2025
[Sedation of infants with congenital hyperinsulinism during PET CAT scanning. A case collection]
F Kork1, O Blankenstein, W Mohnike
1Universitätsklinik für Anästhesiologie und operative Intensivmedizin, Charité-Universitätsmedizin Berlin, Berlin, Deutschland.
Insights
Positron emission tomography with 18F-labeled L-DOPA aids in planning surgery for infants with congenital hyperinsulinism. Maintaining stable glucose homeostasis through sedation and IV glucose infusion is crucial for optimal imaging results.
Area of Science:
- Pediatric Endocrinology
- Nuclear Medicine
- Surgical Planning
Background:
- Congenital hyperinsulinism (CHI) is a condition requiring precise surgical intervention.
- Positron emission tomography (PET) with 18F-labeled L-DOPA is a key diagnostic tool for CHI.
- Optimal PET imaging necessitates specific patient preparation.
Purpose of the Study:
- To outline the optimal conditions for performing 18F-labeled L-DOPA PET scans in infants with CHI.
- To detail the necessary protocols for ensuring patient stability and accurate diagnostic results.
Main Methods:
- Continuous propofol sedation administered by an anesthesiologist.
- Intravenous glucose infusion to maintain stable glucose homeostasis.
- Regular blood glucose monitoring and adjustment of infusion rates.
Main Results:
- Sedation and controlled glucose infusion enable infants to remain still for extended imaging periods.
- Stable glucose homeostasis prevents hypoglycemia, which can affect imaging quality.
- Anesthesiologist-guided management ensures patient safety and optimal scan conditions.
Conclusions:
- Careful patient management, including sedation and glucose control, is essential for successful 18F-labeled L-DOPA PET in infants with CHI.
- This approach optimizes diagnostic accuracy for surgical planning in congenital hyperinsulinism.
Abstract:
Infants with congenital hyperinsulinism may require a positron emission tomography examination with 18F-labeled L-DOPA for the evaluation and planning of surgical interventions. To obtain optimal results it is important for the child to be in a stress-free situation because a stable glucose homoeostasis must be maintained by intravenous glucose infusion. The infant needs to lie calm over a long period of time to obtain optimal results. Sedation for this purpose can be achieved with a continuous infusion of propofol and should be carried out by an anesthesiologist. Additionally blood glucose measurements must be regularly carried out and the glucose infusion must be adjusted to prevent hypoglycemia.
Related Concept Videos
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
01:30Radiological Investigation I: X-ray and CT
01:14Imaging Studies I: CT and MRI
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...