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Updated: Jul 2, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
[Macrophagic myofascitis vs atypical Whipple's disease]
K Spengos1, A Vontzalidis, S Vassilopoulou
1Eginition Krankenhaus, Neurologische Universitätsklinik Athen, Vas. Sofias 72, 11528, Athen, Greece. konstantinos.spengos@gmail.com
Abstract:
A 39-year-old man presented pronounced asthenia and diffuse myalgias 8 months after a vaccination against the tetanus toxoid. Muscle biopsy disclosed infiltration of the perimysium and endomysium by densely packed, PAS-positive macrophages. Tropheryma whippelii detection in blood and faeces allowed the initial assumption of atypical Whipple's disease with isolated muscle involvement. However, the histological detection of aluminium-containing macrophages by means of Morin stain immunofluorescence established the diagnosis of macrophagic myofascitis in an obviously asymptomatic T. whippelii carrier.
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