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The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

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Published on: August 2, 2017

Equine placenta expresses glutamine synthetase.

Hélio C Manso Filho¹, Helena E Costa, Guoyao Wu

¹Equine Science Center, Department of Animal Sciences, Rutgers University, New Brunswick, NJ 08901, USA.

Veterinary Research Communications

|August 30, 2008

Summary

The equine placenta, especially the pregnant horn, synthesizes significant amounts of glutamine, an essential amino acid for fetal development. This study highlights the placenta

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Glutamine Flux Imaging Using Genetically Encoded Sensors

Glutamine Flux Imaging Using Genetically Encoded Sensors

Published on: July 31, 2014

Area of Science:

Reproductive Biology
Equine Science
Biochemistry

Background:

Developing fetuses in most mammals rely heavily on glutamine from maternal circulation and placental synthesis.
Glutamine is crucial for fetal development, necessitating a thorough understanding of its synthesis pathways.

Purpose of the Study:

To investigate the role and capacity of the equine placenta in glutamine synthesis.
To quantify glutamine and related amino acid levels in equine placental tissue and amniotic fluid.

Main Methods:

Sampling of placental tissues from Standardbred mares post-parturition and during diestrus.
Detection and quantification of glutamine synthetase protein in placental tissues.
Amino acid profiling of placental tissue and amniotic fluid.

Main Results:

Glutamine synthetase protein was significantly higher in the pregnant horn of the placenta compared to the non-pregnant horn.
Glutamine was the second most abundant amino acid in equine amniotic fluid.
Glycine, glutamate, and glutamine were the most abundant amino acids in placental tissue.

Conclusions:

The equine placenta, particularly the pregnant horn, possesses a substantial capacity for glutamine synthesis.
Glutamine is vital for the equine fetus, with the placenta playing a key role in its supply.