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Updated: Jul 2, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
Published on: August 8, 2022
Molecular cloning, sequence analysis and expression studies of a novel GAmyb homologous gene, hvmyb
Abstract:
Using a known GAmyb gene as the probe, two fully identical clones were isolated from a barley aleurone cDNA library. Sequence analysis showed that their 5' termini are highly homologous to the 3' termini of GAmyb (97%) and their 3' termini share no significant homology with any myb genes. Therefore, the deduced protein may hold intact putative GAmyb activation domain but lack the normal DNA-binding domain. Northern blot reveals that hvmyb expression in barley aleurone layers is strongly up-regulated by gibberellin (GA) and down-regulated by abscisic acid (APIA). The tissue-and developmental-stage-specificity of hvmyb was also found, which was only expressed in barley aleurone cells and dropped to non-detectable level soon after germination.

