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Related Experiment Videos

Semen parameters in men with and without proven chronic prostatitis.

W Weidner1, C Jantos, H G Schiefer

  • 1Department of Urology, University of Giessen, Germany.

Archives of Andrology
|May 1, 1991
PubMed
Summary

Diagnosing chronic prostatitis involves analyzing prostatic secretions. Antibody-coated bacteria (ACB) and significant bacteriospermia are key indicators differentiating chronic bacterial prostatitis from other forms.

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Area of Science:

  • Urology
  • Microbiology
  • Andrology

Background:

  • Chronic prostatitis is a common condition in men, often presenting diagnostic challenges.
  • Accurate classification into chronic bacterial prostatitis (CBP), nonbacterial prostatitis (NBP), and prostatodynia (Pd) is crucial for effective treatment.
  • Distinguishing between these conditions based on prostatic secretions and ejaculate analysis is essential.

Purpose of the Study:

  • To evaluate the diagnostic utility of ejaculate analysis, including bacterial counts and antibody-coated bacteria (ACB), in classifying chronic prostatitis.
  • To compare semen parameters and inflammatory markers across different prostatitis classifications and healthy controls.

Main Methods:

  • A cohort of men diagnosed with CBP, NBP, Pd, and healthy volunteers underwent a two-fold ejaculate analysis.

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  • Analysis included sperm count, motility, morphology, bacterial load, leukocyte counts, ACB detection, ureaplasma detection, and chlamydia testing.
  • WHO criteria were used for semen analysis, and statistical comparisons were made between groups.

    • Main Results:

    • No significant differences in sperm density, motility, or morphology were observed between the groups.
    • Significant bacteriospermia (≥10^3 bacteria/ml) was found in 47% of CBP patients, compared to lower percentages in NBP, Pd, and control groups.
    • ACB positivity was significantly higher in CBP (31/32) compared to NBP (3/102), Pd (9/142), and controls (0/42).
    • Elevated leukocytes were noted in CBP and NBP patients, with higher levels in NBP/Pd patients with chlamydial infections.

    Conclusions:

    • Antibody-coated bacteria (ACB) and significant bacteriospermia are highly indicative of chronic bacterial prostatitis (CBP).
    • Ejaculate analysis, particularly ACB testing, offers a valuable tool for differentiating CBP from nonbacterial prostatitis and prostatodynia.
    • Semen parameters alone are insufficient for classifying chronic prostatitis, highlighting the importance of microbiological and immunological markers.