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Preparation of Mechanically Stable Self-Assembled Peptides Hydrogels
05:24

Preparation of Mechanically Stable Self-Assembled Peptides Hydrogels

Published on: September 6, 2024

Serum stability of peptides.

Håvard Jenssen1, Stein Ivar Aspmo

  • 1Centre for Microbial Diseases and Immunity Research, University of British Columbia, Vancouver, British Columbia, Canada.

Methods in Molecular Biology (Clifton, N.J.)
|August 30, 2008
PubMed
Summary

Drug-resistant microbes are increasing, driving research into peptide therapeutics. This chapter focuses on assays to measure peptide stability in serum for potential new drug development.

Area of Science:

  • Microbiology and Pharmacology
  • Drug Discovery and Development

Background:

  • Rising global incidence of drug-resistant pathogenic microbes necessitates novel therapeutic strategies.
  • Antimicrobial peptides are a promising area for new drug design due to natural occurrence and low toxicity.

Purpose of the Study:

  • To review and discuss assays for evaluating peptide stability in serum.
  • To address challenges in developing peptide therapeutics for systemic use.

Main Methods:

  • In vitro assays for peptide stability assessment in serum.
  • In vivo methods for measuring peptide stability in biological systems.

Main Results:

  • Discussion of various methodologies for peptide stability testing.

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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

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Last Updated: Jul 2, 2026

Preparation of Mechanically Stable Self-Assembled Peptides Hydrogels
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Preparation of Mechanically Stable Self-Assembled Peptides Hydrogels

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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

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  • Highlighting the importance of serum stability for therapeutic efficacy.

    • Conclusions:

    • Accurate assessment of peptide stability in serum is crucial for advancing peptide-based drug development.
    • Development of robust assays is key to overcoming challenges in systemic peptide therapy.