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Updated: Jul 2, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
Hyperthermic intraperitoneal chemotherapy: nomenclature and modalities of perfusion
Olivier Glehen1, Eddy Cotte, Shigeki Kusamura
1Department of Oncologic surgery, Centre Hospitalo-Universitaire Lyon Sud, Pierre Bénite Cedex, France. olivier.glehen@chu-lyon.fr
Abstract:
Following international consensus, HIPEC should be the acronym used in the scientific literature to refer to the hyperthermic intraperitoneal chemotherapy. Several modalities of perfusion are used to deliver HIPEC: open abdominal technique (Coliseum), closed abdominal technique, peritoneal cavity expander, semi-opened abdominal technique. There is no sufficient evidence in literature confirming the superiority of one technique over the others in terms of outcome, morbidity and safety to the personnel of the operating theatre. Each option has its own operational advantages and disadvantages and future prospective studies must be conducted to establish which one is the best alternative. Today, the best technique is the one which is routinely used and improved into each specialized institution involved in the management of peritoneal surface malignancy.

