Related Experiment Video
Updated: Jul 2, 2026

11:38
In vivo Imaging of Optic Nerve Fiber Integrity by Contrast-Enhanced MRI in Mice
Published on: July 22, 2014
Positive contrast visualization of nitinol devices using susceptibility gradient mapping.
Evert-jan P A Vonken1, Michael Schär, Matthias Stuber
1Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. evertjan@isi.uu.nl
Magnetic Resonance in Medicine
|August 30, 2008
Summary
This study introduces a new MRI postprocessing technique for positive contrast visualization of nitinol devices. The method maps susceptibility gradients, improving device imaging beyond traditional signal loss methods.
Area of Science:
- Medical Imaging
- Materials Science
- Biomedical Engineering
Background:
- Traditional MRI visualization of nitinol devices relies on signal loss from T(2)* effects.
- Local susceptibility differences in nitinol cause signal dropout, hindering clear visualization.
- Positive contrast imaging for nitinol devices remains a challenge in MRI.
Purpose of the Study:
- To adapt a postprocessing method for positive contrast MRI visualization of nitinol devices.
- To map induced susceptibility gradients for enhanced device imaging.
- To demonstrate the effectiveness of the new method on nitinol implants.
Main Methods:
- Adapted a postprocessing technique using regular gradient-echo MR images.
- Mapped k-space shifts via Fourier analysis and center-of-mass calculation.
- Generated quantitative maps of local susceptibility gradients for contrast.
Main Results:
- Successfully generated positive contrast images of nitinol devices.
- The method maps susceptibility gradients, creating device contrast against a noise-only background.
- Positive signal response is dependent on the selected voxel neighborhood size.
Conclusions:
- The adapted postprocessing method enables positive contrast MRI visualization of nitinol devices.
- This technique overcomes limitations of traditional signal loss-based MRI.
- The method offers improved imaging for nitinol implants like wires and stents.
Related Concept Videos
Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Magnetic Susceptibility and Permeability
In linear magnetic materials, like paramagnets and diamagnets, magnetization is proportional to the magnetic field intensity. The constant of proportionality, a dimensionless number, is called magnetic susceptibility. The value of the susceptibility depends on the type of material.
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...

