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Cell swelling-induced peptide hormone secretion.

Vladimir Strbák1, Julius Benicky, Susan E Greer

  • 1Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava 83306, Slovakia. vladimir.strbak@savba.sk

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Cell swelling triggers exocytosis, releasing hormones and enzymes from various cells. This process is crucial for cell signaling and function, impacting endocrine and exocrine systems.

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Area of Science:

  • Cell Biology
  • Endocrinology
  • Signal Transduction

Background:

  • Cell volume regulation is a fundamental aspect of cell function.
  • Cell swelling is increasingly recognized as a significant cellular stimulus.
  • Intracellular signaling pathways are intricately linked to cell volume changes.

Purpose of the Study:

  • To investigate the role of cell swelling in inducing exocytosis.
  • To explore the range of substances released via cell swelling-induced exocytosis.
  • To highlight the significance of cell swelling in cellular secretion processes.

Main Methods:

  • Induction of cell swelling using an anisomotic environment.
  • Exposure to permeant molecules like ethanol or urea to induce swelling.
  • Observation and quantification of exocytosis in various cell types.

Main Results:

  • Cell swelling powerfully induces exocytosis of intracellular secretory vesicles.
  • Secretion of numerous hormones (e.g., TRH, GnRH, insulin, renin) is stimulated by cell swelling.
  • Exocrine pancreatic enzymes and myeloperoxidase secretion are also induced by cell swelling.

Conclusions:

  • Cell swelling is a potent stimulus for exocytosis across diverse cell types.
  • This mechanism is vital for the release of hormones and other bioactive substances.
  • Understanding cell swelling-induced exocytosis offers insights into cellular regulation and function.