Heparin overdose scare in 14 babies at Texas hospital

    Healthcare Benchmarks and Quality Improvement
    |August 30, 2008
    PubMed

    Insights

    Accurate medication dosing for children requires weighing them in kilograms. Thoroughly testing computerized provider order entry (CPOE) systems before implementation is crucial for safe pediatric prescribing.

    Area of Science:

    • Pediatric pharmacology
    • Clinical informatics

    Background:

    • Pediatric medication dosing presents unique challenges compared to adults.
    • Ensuring accurate drug administration in children is critical for patient safety and treatment efficacy.

    Purpose of the Study:

    • To highlight key considerations for safe medication dosing in pediatric patients.
    • To emphasize the importance of accurate weight measurement and system implementation for pediatric prescribing.

    Main Methods:

    • Review of best practices in pediatric pharmacotherapy.
    • Guidance on utilizing clinical decision support tools and electronic prescribing systems.

    Main Results:

    • Accurate pediatric medication dosing necessitates using patient weight in kilograms.
    • Thorough validation of computerized provider order entry (CPOE) systems is essential prior to clinical use.

    Conclusions:

    • Standardizing weight measurement to kilograms is a fundamental step in safe pediatric medication management.
    • Effective implementation of CPOE systems requires comprehensive pre-implementation testing to prevent errors.

    Related Concept Videos

    Pharmaceutical Poisoning: Potential Scenarios01:26

    Pharmaceutical Poisoning: Potential Scenarios

    Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
    Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

    Anticoagulant Drugs: Low-Molecular-Weight Heparins

    Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
    Drug Dosing: Infants and Children01:29

    Drug Dosing: Infants and Children

    Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
    Teratogenicity01:07

    Teratogenicity

    The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
    Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

    Pharmacokinetics in Pediatric Patients: Drug Excretion

    In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...