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Related Experiment Video

Updated: Jul 2, 2026

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
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Headache disorders in developing countries: research over the past decade.

F J Mateen1, T Dua, T Steiner

  • 1Department of Mental Health and Substance Abuse, World Health Organization, Geneva, Switzerland.

Cephalalgia : an International Journal of Headache
|August 30, 2008
PubMed
Summary

Research on primary headache disorders in low and middle-income countries (LAMI) is limited, with most studies focusing on migraine and few on treatment. This highlights a need for targeted research policy in the developing world.

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Area of Science:

  • Neurology
  • Global Health Research

Background:

  • The majority of individuals with primary headache disorders reside in developing nations.
  • The extent of primary headache research originating from low and middle-income countries (LAMI) remains uncharacterized.

Purpose of the Study:

  • To characterize the contribution of LAMI countries to primary headache research between 1997 and 2006.
  • To identify research gaps in headache disorders within the developing world.

Main Methods:

  • A comprehensive literature search was conducted across 67 databases using terms related to headache, primary disorders, migraine, and LAMI countries.
  • Publications from 1997-2006 with English abstracts were included and analyzed for study characteristics.

Main Results:

  • 227 publications from 32 LAMI countries were identified.
  • Over half of the research originated from Brazil, Turkey, and Iran.
  • Migraine was the predominant focus, with only 29.5% of articles addressing headache treatment.

Conclusions:

  • Understanding of headache disorders in LAMI countries is based on limited research from a few nations.
  • Identifying research gaps is crucial for developing effective research policies in the developing world.