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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Related Experiment Video

Updated: Jul 2, 2026

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

Published on: October 13, 2023

Headache and multiple sclerosis: a population-based case-control study in Catania, Sicily.

A Nicoletti1, F Patti, S Lo Fermo

  • 1Department of Neurosciences, University of Catania, Catania, Italy.

Cephalalgia : an International Journal of Headache
|August 30, 2008
PubMed
Summary

People with multiple sclerosis (MS) are more likely to experience headaches. This population-based study found a significant association, suggesting a potential link between MS and headache conditions.

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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Last Updated: Jul 2, 2026

Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

Area of Science:

  • Neurology
  • Epidemiology

Background:

  • Headache is a common neurological symptom.
  • The relationship between multiple sclerosis (MS) and headache requires further investigation.

Purpose of the Study:

  • To investigate the association between multiple sclerosis (MS) and headache in a defined population.
  • To determine if headache prevalence differs between MS patients and the general population.

Main Methods:

  • A population-based case-control study was conducted in Catania, Sicily.
  • 155 incident MS patients and 101 controls underwent standardized headache interviews.
  • Headache diagnoses followed International Headache Society criteria.

Main Results:

  • 57.4% of MS patients reported headaches compared to 37.2% of controls.
  • A significant association was found between MS and headache (adjusted OR = 2.18).
  • The frequency of headaches was notably higher in the MS population.

Conclusions:

  • Headache is significantly more common in individuals with multiple sclerosis.
  • Findings support a potential association between MS and headache conditions.
  • Further research is warranted to elucidate the underlying mechanisms.