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Transabdominal chorion villus sampling: a safe and reliable procedure.
H P Robinson1, L C de Crespigny, A C Ngu
1Royal Women's Hospital, Freemasons Day Care Procedure Centre, Melbourne.
The Australian & New Zealand Journal of Obstetrics & Gynaecology
|February 1, 1991
Summary
Transabdominal chorion villus sampling (TACVS) is a safe and reliable procedure for early pregnancy diagnosis. This study found a low pregnancy loss rate of 2% and a high success rate for obtaining results.
Area of Science:
- Obstetrics and Gynecology
- Prenatal Diagnostics
- Fetal Medicine
Background:
- Transabdominal chorion villus sampling (TACVS) is an invasive prenatal diagnostic technique.
- Assessing the safety and efficacy of TACVS is crucial for clinical decision-making.
- Previous studies have reported varying success and complication rates.
Purpose of the Study:
- To determine the pregnancy loss rate following transabdominal chorion villus sampling (TACVS).
- To identify factors contributing to pregnancy loss and procedural difficulties.
- To evaluate the rate of achieving clinically relevant results from TACVS.
Main Methods:
- A complete follow-up of 578 patients who underwent TACVS was conducted.
- Data on procedural difficulties, tissue acquisition, and pregnancy outcomes were collected.
- Statistical analysis was performed to assess the relationship between factors and outcomes.
Main Results:
- An adequate tissue volume was obtained in 98.1% of patients.
- A clinically relevant result was achieved in 95.5% of cases, improving to 96.3% later in the study.
- The total fetal loss rate was 2%, with only 0.5% attributed to missed abortion within 4 weeks post-procedure.
Conclusions:
- Transabdominal chorion villus sampling (TACVS) is a reliable procedure with a high safety profile.
- Increasing operator experience reduces procedural difficulties.
- Women with a retroverted uterus may experience a higher rate of procedural issues.