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Updated: Jul 2, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

Cryptococcal meningitis in an immunocompetent adolescent.

A L T Ma¹, N C Fong, C W Leung

¹Department of Paediatrics & Adolescent Medicine, Princess Margaret Hospital, Hong Kong. maalison2000@gmail.com

Annals of Tropical Paediatrics

|August 30, 2008

Summary

Cryptococcus neoformans meningitis is rare in healthy children. This report details a successful treatment of a Chinese adolescent with intravenous amphotericin and oral flucytosine.

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Last Updated: Jul 2, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

Area of Science:

Infectious Diseases
Pediatrics
Mycology

Background:

Cryptococcus neoformans is an opportunistic fungal pathogen.
Cryptococcal meningitis is uncommon in immunocompetent individuals, particularly children.
This case highlights a rare presentation in a pediatric population.

Observation:

A healthy Chinese adolescent presented with symptoms suggestive of meningitis.
Cerebrospinal fluid analysis confirmed the presence of Cryptococcus neoformans.
The patient had no known underlying immunodeficiency.

Findings:

The adolescent received treatment with intravenous amphotericin B and oral flucytosine.
Clinical and microbiological resolution of cryptococcal meningitis was achieved.
The patient demonstrated a favorable response to the prescribed antifungal regimen.

Implications:

This case underscores the importance of considering Cryptococcus neoformans in the differential diagnosis of meningitis, even in immunocompetent children.
Successful treatment outcomes can be achieved with standard antifungal therapies.
Further research may explore the epidemiology and specific risk factors in pediatric populations.