Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cranial and Spinal Meninges

Cranial and Spinal Meninges

The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...

Cranial Bones: Superior and Posterior View

Cranial Bones: Superior and Posterior View

The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...

Sutures of the Skull

Sutures of the Skull

The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...

Extracellular Matrix

Extracellular Matrix

Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...

The Bone Matrix

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Perianeurysmal edema in giant intracranial aneurysms in relation to aneurysm location, size, and partial thrombosis.

Journal of neurosurgery·2015

Same author

Quantifying unruptured giant intracranial aneurysms by measuring diameter and volume--a comparative analysis of 69 cases.

Acta neurochirurgica·2014

Same author

Clonal analysis in recurrent astrocytic, oligoastrocytic and oligodendroglial tumors implicates IDH1- mutation as common tumor initiating event.

PloS one·2012

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 2, 2026

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

Collagen matrix in decompressive hemicraniectomy.

Jorn A Horaczek¹, Jan Zierski, Alexander Graewe

¹Department of Neurosurgery, Neukolln-Hospital Berlin, Berlin, Germany. post@horaczek.de

|September 9, 2008

Summary

Collagen matrix use during hemicraniectomy surgery significantly reduced operating time and cerebrospinal fluid effusion rates. This innovative approach offers potential cost savings and improved patient outcomes in neurosurgery.

More Related Videos

Accessing the Porcine Brain via High-Speed Pneumatic Drill Craniectomy

Accessing the Porcine Brain via High-Speed Pneumatic Drill Craniectomy

Published on: July 5, 2024

Microvascular Decompression: Salient Surgical Principles and Technical Nuances

Microvascular Decompression: Salient Surgical Principles and Technical Nuances

Published on: July 5, 2011

Related Experiment Videos

Last Updated: Jul 2, 2026

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

Accessing the Porcine Brain via High-Speed Pneumatic Drill Craniectomy

Accessing the Porcine Brain via High-Speed Pneumatic Drill Craniectomy

Published on: July 5, 2024

Microvascular Decompression: Salient Surgical Principles and Technical Nuances

Microvascular Decompression: Salient Surgical Principles and Technical Nuances

Published on: July 5, 2011

Area of Science:

Neurosurgery
Surgical Innovation
Biomaterials in Medicine

Background:

Decompressive hemicraniectomy is a critical intervention for intractable intracranial hypertension.
Dural closure and dissection during hemicraniectomy and subsequent cranioplasty present surgical challenges.

Purpose of the Study:

To evaluate the efficacy of a collagen matrix as an onlay graft during hemicraniectomy.
To assess the impact of collagen matrix on operating time and dural dissection.
To determine the effect on complication rates and patient recovery.

Main Methods:

Prospective randomized study involving 34 patients undergoing hemicraniectomy.
Patients were randomized to receive collagen matrix or undergo conventional procedures.
Key metrics included operating time, complication rates (CSF effusion), and functional outcome scores.

Main Results:

Collagen matrix reduced combined hemicraniectomy and cranioplasty operating time by 19.7%.
Cerebrospinal fluid effusion rates decreased from 58% (control) to 13% with collagen matrix.
85% of surgeons found the collagen matrix procedure easier to perform.

Conclusions:

Collagen matrix application effectively reduces operative time for hemicraniectomy and cranioplasty.
The use of collagen matrix lowers complication rates, particularly cerebrospinal fluid effusion.
This technique shows potential for reduced treatment time and cost savings without impacting rehabilitative outcomes.