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Published on: March 26, 2020
Carcinoma-associated retinopathy-an electrophysiological and immunohistochemical correlation
Barbara Link1, Ursula Schlötzer-Schrehardt, Anselm Jünemann
1Department of Ophthalmology, University of Erlangen-Nuernberg, Erlangen, Germany. barbara.link@uk-erlangen.de
Purpose:
To correlate the clinical, electrophysiological, and immunohistochemical findings in patients suffering from carcinoma-associated retinopathy.
Methods:
Four patients with visual loss were included in this retrospective, observational consecutive case series. Electrophysiology and immunohistochemical analysis were performed to confirm the diagnosis of carcinoma-associated retinopathy.
Results:
Immunohistochemistry revealed a marked interindividual variability of antibody reactions against different retinal cell layers of individual patients. The electrophysiological changes corresponded to the respective immunohistochemical findings.
Conclusion:
Carcinoma-associated retinopathy is a heterogeneous disease, caused by different antiretinal antibodies and leading to different electrophysiological abnormalities. Diagnosis should not be delayed as undetected and thus untreated malignancy can be the cause.
