Related Experiment Video

Updated: Jul 2, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

Developments in the management of autosomal dominant polycystic kidney disease

Amirali Masoumi1, Berenice Reed-Gitomer, Catherine Kelleher

  • 1Department of Medicine, Health Sciences Center, University of Colorado School of Medicine Denver, CO 80262, USA.

Therapeutics and Clinical Risk Management
|August 30, 2008
PubMed

Insights

Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder causing kidney cysts and enlargement. Early diagnosis and treatment of hypertension may slow disease progression and prevent complications.

Area of Science:

  • Nephrology
  • Genetics
  • Hereditary Diseases

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent, life-threatening genetic disorder.
  • It is characterized by progressive cyst development, leading to renal enlargement and functional decline.
  • ADPKD is a leading cause of end-stage renal disease (ESRD) and involves multisystemic abnormalities.

Purpose of the Study:

  • To review prognostic factors for ADPKD progression.
  • To highlight the importance of early diagnosis and management.
  • To emphasize the role of hypertension control in mitigating complications.

Main Methods:

  • Review of recent studies on ADPKD.
  • Identification of prognostic factors for renal impairment.
  • Analysis of therapeutic strategies for hypertension management.

Main Results:

  • Key prognostic factors include gender, race, age, proteinuria, hematuria, hypertension, and left ventricular mass index (LVMI).
  • Renin-angiotensin-aldosterone system inhibitors are effective in managing hypertension.
  • Treatment may reduce LVMI, cardiovascular risks, and slow renal disease progression.

Conclusions:

  • Early identification of prognostic factors is crucial for managing ADPKD.
  • Aggressive hypertension management is vital for slowing renal disease progression.
  • Targeted therapies can improve outcomes and reduce morbidity/mortality in ADPKD patients.

Keywords:
cerebral aneurysmshypertensionleft ventricular hypertrophyliver cystsrenal pain

More Related Videos

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium08:46

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Published on: September 1, 2015

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...