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Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
Ischemic Stroke ll: Pathophysiology01:15

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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

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Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Transient Ischemic Attack l: Introduction01:26

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A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
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Updated: Jul 2, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Treating acute ischemic stroke.

Marc Fisher1, Birgul Bastan

  • 1UMASS/Memorial Healthcare, 119 Belmont Street, Worcester, MA 01605, USA. FisherM@ummhc.org

Current Opinion in Drug Discovery & Development
|August 30, 2008
PubMed
Summary
This summary is machine-generated.

Acute ischemic stroke (AIS) treatment is limited by a narrow time window for intravenous thrombolysis. Expanding treatment options and timeframes is crucial for improving patient outcomes in AIS.

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Prehospital Thrombolysis: A Manual from Berlin
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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
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Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

Area of Science:

  • Neurology
  • Emergency Medicine
  • Vascular Medicine

Background:

  • Acute ischemic stroke (AIS) is a prevalent neurological disorder with limited approved treatments.
  • Intravenous tissue plasminogen activator (iv t-PA) is the primary therapy but has a strict 3-hour time window.
  • Current therapeutic strategies face significant limitations in expanding treatment accessibility.

Purpose of the Study:

  • To review the current landscape of acute ischemic stroke therapies.
  • To discuss strategies for extending the therapeutic time window for AIS.
  • To evaluate the efficacy and limitations of existing and emerging AIS treatments.

Main Methods:

  • Literature review of current AIS treatment guidelines and research.
  • Analysis of therapeutic interventions including thrombolysis, mechanical recanalization, and neuroprotection.
  • Evaluation of imaging techniques for identifying salvageable brain tissue (ischemic penumbra).

Main Results:

  • Intravenous t-PA remains the only approved therapy, with efficacy dependent on rapid administration.
  • Intra-arterial therapies and mechanical recanalization devices show promise but are not universally approved for stroke.
  • Neuroprotective agents have consistently failed to demonstrate efficacy in clinical trials.

Conclusions:

  • Expanding the therapeutic window for AIS is a critical unmet need.
  • Further research into advanced imaging and novel therapeutic approaches is essential.
  • The future of neuroprotection for acute ischemic stroke remains uncertain, requiring innovative strategies.