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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Related Experiment Video

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In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats
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Positron emission tomography for modeling pathophysiological processes in vivo.

N Harry Hendrikse1, Gert Luurtsema, Astrid A M van der Veldt

  • 1Department of Nuclear Medicine & PET Research, VU Medical Center Amsterdam, Amsterdam, The Netherlands. nh.hendrikse@vumc.nl

Current Opinion in Drug Discovery & Development
|August 30, 2008
PubMed
Summary

Positron emission tomography (PET) offers advanced imaging for disease staging and treatment response. This review explores PET tracers in drug development and clinical uses across neurology, oncology, and cardiology.

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Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Pharmacology

Background:

  • Positron emission tomography (PET) is a key imaging modality for visualizing and measuring biological processes.
  • PET is established in disease staging and assessing treatment efficacy.
  • Its potential extends to drug discovery and personalized medicine.

Purpose of the Study:

  • To review the application of various PET tracers in pharmaceutical research and development.
  • To highlight the clinical utility of PET imaging in neurology, oncology, and cardiology.

Main Methods:

  • Literature review of PET tracer applications.
  • Analysis of clinical case studies and research findings.
  • Synthesis of data on PET's role in drug development.

Main Results:

  • PET tracers are vital tools in preclinical and clinical drug development.
  • Significant applications exist in diagnosing and monitoring neurological disorders.
  • PET plays a crucial role in cancer detection, staging, and therapy response assessment.
  • Cardiac imaging with PET aids in diagnosing and managing heart conditions.

Conclusions:

  • PET imaging, utilizing specific tracers, is instrumental in advancing drug development.
  • Clinical applications of PET are expanding in neurology, oncology, and cardiology.
  • PET facilitates personalized treatment strategies and improved patient outcomes.