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Stemina biomarker discovery.

Gabriela G Cezar1, Elizabeth L R Donley

  • 1Department of Animal Science at the University of Wisconsin, WI, USA. ggcezar@wisc.edu

Regenerative Medicine
|August 30, 2008
PubMed
Summary
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Stemina Biomarker Discovery uses human embryonic stem (hES) cells and metabolomics to identify toxicity biomarkers. This human-based system aids drug screening and disease research by analyzing secreted small molecules.

Area of Science:

  • Biotechnology
  • Toxicology
  • Stem Cell Biology

Background:

  • Stemina Biomarker Discovery commercializes technology from the University of Wisconsin.
  • The company integrates metabolomics and human embryonic stem (hES) cell technologies.

Purpose of the Study:

  • To develop a human-based system for identifying toxicity biomarkers.
  • To enable efficient drug screening and development.

Main Methods:

  • Utilizing human embryonic stem (hES) cells and differentiated cell types (neural, heart).
  • Analyzing small molecules in the extracellular secretome using liquid chromatography-mass spectrometry.
  • Mapping biochemical pathway alterations in silico.

Main Results:

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  • Identified a dynamic set of small molecules secreted by hES cells in response to teratogens.
  • Established a method to map alterations in small molecules to identify toxicity biomarkers.
  • Developed an all-human system for toxicity assessment.

Conclusions:

  • The technology provides a human-based approach for drug toxicity screening.
  • Identified small molecules can serve as in vivo biomarkers for toxic response and disease.
  • This platform supports the development of safer drugs and better disease understanding.