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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

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Cortical Neurogenesis: Transitioning from Advances in the Laboratory to Cell-Based Therapies
12:38

Cortical Neurogenesis: Transitioning from Advances in the Laboratory to Cell-Based Therapies

Published on: July 19, 2007

Catalyzing stem cell research.

Lisa Willemse1, Drew Lyall, Michael Rudnicki

  • 1Stem Cell Network, 501 Smyth Road, Room CCW-6293, Ottawa, Ontario, K1H 8L6, Canada. lisa@stemcellnetwork.ca

Regenerative Medicine
|August 30, 2008
PubMed
Summary
This summary is machine-generated.

The Stem Cell Network fostered Canadian research collaborations, leading to innovative technologies and clinical trials. It now aims to bridge the gap between research and real-world applications.

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Area of Science:

  • Regenerative Medicine
  • Biotechnology
  • Health Policy

Background:

  • Established in 2001, the Stem Cell Network (SCN) was the first pan-Canadian initiative to unite researchers, engineers, clinicians, and industry partners.
  • Canada possesses a rich talent pool in stem cell research, providing a strong foundation for the SCN's growth and success.

Purpose of the Study:

  • To foster pan-Canadian collaborations in stem cell research.
  • To advance stem cell technologies and clinical applications.
  • To address ethical, legal, and social issues surrounding stem cell research.

Main Methods:

  • Facilitating interdisciplinary collaborations across academic, clinical, and private sectors.
  • Supporting the development of innovative cell expansion and screening technologies.
  • Initiating early-phase clinical trials for various diseases.

Main Results:

  • Development of novel cell expansion and screening technologies.
  • Successful initiation of clinical trials for stroke, pulmonary hypertension, muscular dystrophy, and cornea replacement.
  • Establishment of leading discourse on ethical, legal, and social implications of stem cell research.

Conclusions:

  • The Stem Cell Network has achieved significant milestones in stem cell research and application.
  • The network is entering its final funding phase with a focus on translating research into clinical practice, commercial products, and public policy.
  • Continued efforts are needed to overcome barriers in the research-to-application pipeline.