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Skin Punch Biopsy Explant Culture for Derivation of Primary Human Fibroblasts
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Skin Punch Biopsy Explant Culture for Derivation of Primary Human Fibroblasts

Published on: July 7, 2013

Cultured skin fibroblasts and their use in genetic counseling

S Cederbaum

    California Medicine
    |September 1, 1973
    PubMed
    Abstract

    No abstract available in PubMed .

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    Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...

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