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Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
Published on: December 14, 2015
Nail is produced by the normal nail bed: a controversy resolved
M Johnson1, J S Comaish, S Shuster
1University Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.
The British Journal of Dermatology
|July 1, 1991
Summary
The nail bed contributes about one-fifth to the final thickness and mass of toenails. This study measured nail properties in toenails from patients after injury.
Area of Science:
- Dermatology
- Anatomy
- Biomechanics
Background:
- The nail plate is formed by the nail matrix, but the contribution of the nail bed to the final nail structure is not fully understood.
- Understanding nail growth and composition is crucial for diagnosing and treating nail disorders.
Purpose of the Study:
- To quantify the contribution of the nail bed to the overall thickness and mass of the toenail.
Main Methods:
- Nail thickness and mass were measured in 21 toenails from 19 patients post-injury.
- Measurements were taken at three specific locations: the mid-point of the lunula, the nail plate distal to the lunula, and the distal end of the nail bed.
Main Results:
- Nail thickness increased significantly from the lunula's midpoint (43%) to its distal margin (81%).
- The nail bed accounted for the remaining thickness increase, contributing approximately one-fifth to the final nail thickness and mass.
- Comparable changes were observed in nail mass.
Conclusions:
- The nail bed plays a significant role in forming the ventral aspect of the nail plate.
- Approximately 20% of the terminal nail's thickness and mass originates from the nail bed, not solely the nail matrix.
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