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Simultaneous determination of imipramine and amitryptiline by derivative spectrophotometry
J M García Fraga1, A I Jiménez Abizanda, F Jiménez Moreno
1Department of Analytical Chemistry, Bromatology and Toxicology, University of La Laguna, Tenerife, Spain.
Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1991
Abstract:
Three methods are proposed for the simultaneous determination of imipramine and amitryptiline by derivative spectrophotometry, one of them using both first- and second-derivative spectra, and the others using the first- and second-derivative spectra, respectively, obtained from a "diode array" spectrophotometer. The methods allow the determination of 0.62-10.14 micrograms ml-1 of imipramine, and 0.63-10.04 micrograms ml-1 of amitryptiline, and have been applied to their determination in blood serum.