Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Software for estimating LD50 and LD90 by logit analysis.

A S Acharya1, N K Acharya, A P Dash

  • 1Regional Medical Research Centre, Indian Council and Medical Research, Chandrasekharpur, Bhubaneswar, Orissa.

Computer Methods and Programs in Biomedicine
|April 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Finishing the task of eliminating neglected tropical diseases (NTDs) in WHO South-East Asia Region: promises kept, challenges, and the way forward.

The Lancet regional health. Southeast Asia·2023
Same author

Resolvin D2 promotes host defense in a 2 - hit model of sepsis with secondary lung infection.

Prostaglandins & other lipid mediators·2022
Same author

Recent advances on T-cell exhaustion in malaria infection.

Medical microbiology and immunology·2018
Same author

Vector-borne diseases in South-East Asia: burdens and key challenges to be addressed.

WHO South-East Asia journal of public health·2017
Same author

Epidemiological features and genetic characterization of virus strains in rotavirus associated gastroenteritis in children of Odisha in Eastern India.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases·2017
Same author

Control of Aedes aegypti and Ae. albopictus, the vectors of dengue and chikungunya, by using pheromone C21 with an insect growth regulator: Results of multicentric trials from 2007-12 in India.

Journal of vector borne diseases·2015
Same journal

Accounting for approximation errors using surrogate-based parameter estimation of cardiac mechanics digital twins.

Computer methods and programs in biomedicine·2026
Same journal

Facial iPPG heatmap patterns based on period-aware autoencoder show association with carotid atherosclerosis towards non-contact hemodynamic assessment.

Computer methods and programs in biomedicine·2026
Same journal

Explainable machine learning models predict liver fibrosis risk and outcome in the general population: Development and multi-cohort external validation.

Computer methods and programs in biomedicine·2026
Same journal

Evaluation of surrogate endpoints for survival outcomes using the surrogate package in R.

Computer methods and programs in biomedicine·2026
Same journal

Relative spectral and frication-based descriptors as numerical indicators of place of articulation shifts in fricatives produced by Polish children.

Computer methods and programs in biomedicine·2026
Same journal

Leaflet resection improves valve expansion and hemodynamic performance in redo TAVI with balloon- and self-expanding transcatheter heart valve configurations.

Computer methods and programs in biomedicine·2026
See all related articles

This study introduces a user-friendly software package for calculating LD50 and LD90 toxicity values using Logit Analysis. The software includes a Chi-squared test for model validation, enhancing toxicological assessments.

Area of Science:

  • Toxicology
  • Biostatistics
  • Software Development

Background:

  • Accurate estimation of median lethal dose (LD50) and lethal dose 90 (LD90) is crucial for toxicological studies.
  • Logit analysis is a standard statistical method for dose-response assessments.
  • Existing software solutions may lack user-friendliness or specific features for toxicity testing.

Purpose of the Study:

  • To develop and present a user-friendly software package for estimating LD50 and LD90 values.
  • To implement Logit Analysis within the software for dose-response modeling.
  • To incorporate a Chi-squared goodness-of-fit test for model validation.

Main Methods:

  • The software was developed using Turbo Pascal programming language.
  • It operates within the MS-DOS environment.

Related Experiment Videos

  • Logit analysis is employed for dose-response estimation, coupled with a Chi-squared test for assessing model fit.

    • Main Results:

    • The software provides a straightforward method for calculating LD50 and LD90.
    • Logit analysis enables robust dose-response curve fitting.
    • The Chi-squared test offers a quantitative measure of how well the model fits the observed data.

    Conclusions:

    • The developed software offers a valuable and accessible tool for toxicological dose-response analysis.
    • Its user-friendly interface and integrated statistical tests facilitate accurate and reliable estimation of lethal doses.
    • This package can aid researchers in conducting and interpreting toxicity studies more efficiently.