[Morphology of placental lobes and clinical pathophysiology in fetal distress]

In order to make a basic study of the etiology, clinical pathophysiology and prevention and management of the fetal distress, an investigation of the placental coefficient, pathomorphology, immunochemistry, and 6 other items were carried out. The placenta lobes of 357 cases with fetal distress were need and a corresponding control was established in each case. The results indicate that the rate of infection of the placenta in fetal distress was 39.5%. The placental coefficient in comparison with the control showed a significant increase (P less than 0.05). Edema of the villi and disease of the villous vascular membrane was prominent. The cytotrophoblast, Hofbauer cell showed cellular compensation proliferation. Estradiol reception (E2R) and progesterone receptor (PgR) were positive mainly in the cyto-trophoblast. The rate of positive finding of Carcinoembryonic Antigen (CEA), AFP and Lysozyme was greater in the fetal distress group in comparison with the control (P less than 0.05). The results indicate that in pregnant women with fetal distress or with risk factors for fetal hypooxygenimia, the administration of anti-infection agents, and improvement of the villus blood circulation as well as giving of anti-amine agents may be beneficial in prevention and management of fetal distress.