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[Effect of tetrandrine and verapamil on left ventricular diastolic and systolic function in essential hypertension]
Insights
Verapamil and Tetrandrine significantly improve left ventricular diastolic function in hypertensive patients. These drugs enhance relaxation and filling without negatively impacting systolic function, offering potential therapeutic benefits.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Hypertension frequently leads to impaired left ventricular (LV) diastolic function.
- Left ventricular hypertrophy is a key factor contributing to diastolic dysfunction in essential hypertension.
Purpose of the Study:
- To investigate the effects of Verapamil (V) and Tetrandrine (T) on the diastolic and systolic function of hypertensive patients.
- To determine if these drugs can improve impaired LV diastolic function.
Main Methods:
- Apexcardiography and echocardiography were used to assess diastolic and systolic function in 34 hypertensive patients.
- Patients received intravenous Verapamil, followed by intravenous Tetrandrine after a washout period.
- Measurements included A/D, TARTI, DATI, and PEP/LVET.
Main Results:
- Intravenous Tetrandrine and Verapamil significantly improved A/D, TARTI, and DATI, indicating enhanced diastolic function.
- No significant changes were observed in PEP/LVET, suggesting preserved systolic function.
- Both drugs demonstrated a positive impact on LV diastolic function.
Conclusions:
- Verapamil and Tetrandrine can significantly improve left ventricular diastolic function in patients with essential hypertension.
- These pharmacological interventions appear to do so without adverse effects on systolic function.
- The findings suggest a potential therapeutic role for V and T in managing hypertensive heart disease.
Abstract:
By using apexcardiography and echocardiography, the diastolic and systolic function of 34 hypertensive patients were studied. The results indicated that left ventricular (LV) hypertrophy is one of the important factors in impairing LV diastolic function in essential hypertension. By using self-control method, Verapamil(V) was injected intravenously. Relative A wave to total diastolic amplitude (A/D), total apexcardiographic relaxation time index (TARTI), diastolic amplitude time index (DATI) and PEP/LVET were measured. After 5 half-lives of V, intravenous Tetrandrine (T) was given, all the measurements were repeated in the same way. The data revealed that A/D, TRATI and DATI improved significantly after intravenous T and V as well, yet PEP/LVET showed no significant change. It, therefore, seems clear that both T and V could induce a significant improvement in LV diastolic function without any apparent adverse influence on systolic function.