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[Hemolytic reaction resulting from propafenone administration].

Z Q Zeng1, L Zhu

  • 1Beijing Hospital.

Zhonghua Nei Ke Za Zhi
|April 1, 1991
PubMed
Summary

Propafenone can cause rare hemolytic reactions, an immune complex type of hemolysis, in susceptible patients. Prompt cessation of the drug and supportive care led to recovery.

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Area of Science:

  • Pharmacology
  • Hematology
  • Immunology

Context:

  • Propafenone is an antiarrhythmic medication.
  • Adverse reactions to propafenone are documented.
  • Hemolytic reactions have not been previously reported with propafenone.

Purpose:

  • To report the first documented cases of hemolytic reactions associated with intravenous propafenone administration.
  • To characterize the clinical presentation and potential mechanism of these reactions.

Summary:

  • Four episodes of hemolytic reactions occurred in three patients after receiving intravenous propafenone.
  • Reactions manifested hours post-administration, with one case complicated by heart failure and shock.
  • Discontinuation of propafenone and supportive care resolved hemolysis, with toxicological studies ruling out drug degradation or contamination.

Impact:

  • Highlights a previously unrecognized adverse drug reaction of propafenone.
  • Suggests an immune complex-mediated mechanism, likely due to patient-specific allergic constitution.
  • Informs clinical vigilance for potential hemolytic reactions in patients treated with propafenone.

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