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Radioprotective effect of dextran sulphate and aerogenic hypoxia on intestinal crypt stem cells in mice
A Vacek1, O A Konoplyanikova, A G Konoplyanikov
1Institute of Biophysics, Czechoslovak Academy of Sciences, Brno.
Folia Biologica
|January 1, 1991
Abstract:
A single intraperitoneal injection of dextran sulphate given 6 h before irradiation produced higher numbers of microcolonies of intestinal crypt stem cells in whole-body irradiated mice than injection of saline in control mice. If dextran sulphate and hypoxia are combined, the radioprotective effect of hypoxia on intestinal crypt stem cells depends on the time interval between irradiation and administration of dextran sulphate.