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Related Experiment Videos

Coumarin-induced skin necrosis.

L W Brooks1, F X Blais

  • 1Riverside Hospital, Trenton, Mich.

The Journal of the American Osteopathic Association
|June 11, 1991
PubMed
Summary
This summary is machine-generated.

Coumarin skin necrosis is a rare complication of anticoagulant therapy, causing painful skin lesions and potential gangrene. Early recognition and management are crucial for patient outcomes.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Pathology

Background:

  • Coumarin anticoagulants are widely used but can cause rare, severe side effects.
  • Coumarin skin necrosis is an unpredictable complication, often presenting between days 3-6 of therapy.
  • This condition involves painful skin lesions progressing to gangrene, linked to dermal and subcutaneous vein thrombosis.