Related Experiment Video
Updated: Jul 2, 2026

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
Published on: June 21, 2024
Clonazepam for chemotherapy-induced nausea and vomiting (CINV)
Minako Koga1, Momoe Nakadozono, Kazutaka Nukariya
1Department of Psychiatry, Machida Municipal Hospital, Machida-shi, Tokyo, 194-0023, Japan. mi-na@pd5.so-net.ne.jp
Background:
A 51-year-old woman experienced refractory chemotherapy-induced nausea and vomiting (CINV) in spite of extensive antiemetic therapy, including 5-HT3 antagonists, corticosteroids, dopamine antagonists and antihistamines.
Case Report:
We administered the patient clonazepam. After taking clonazepam, the patient fully recovered from the nausea and vomiting and never experienced them again.
Conclusion:
Clonazepam may be useful in the control of CINV. We believe that clonazepam contributed to the favorable outcome by expressing an anxiolytic and an anticonvulsant effect on myoclonus. The efficacy of clonazepam in this indication of prevention of CINV warrants further investigation.
Related Concept Videos
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Pathophysiology of Vomiting