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Updated: Jul 2, 2026
The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
Value of procollagen type 1 amino-terminal propeptide in patients with renal cell carcinoma
M Klepzig1, H Sauer-Eppel, D Jonas
1Department of Laboratory Medicine-Internal Medicine, Hospital of the Johann Wolfgang Goethe University, Frankfurt am Main, Germany. martina.klepzig@gmx.de
Background:
The aim of the study was to investigate whether the bone turnover marker procollagen type 1 amino-terminal propeptide (P1NP) could be useful for the early detection of bone metastases in patients with renal cell carcinoma (RCC) and if chemotherapy influences P1NP concentrations in patients with bone metastases.
Patients And Methods:
Serum samples of 36 patients were analyzed using a specific immunoassay. The patients were divided into three groups: 24 patients without metastatic spread, 6 patients with untreated bone metastases and 6 patients who had received sorafenib.
Results:
The P1NP concentration was significantly higher (p< or =0.001) in the patients with bone metastases (median: 396.10 ng/ml) than in those without bone involvement (median: 35.53 ng/ml). The patients treated with sorafenib showed levels within the normal range (median: 28.96 ng/ml).
Conclusion:
P1NP is a significant diagnostic marker for the development of bone metastases in patients with RCC and could help to evaluate the progress of chemotherapy.
