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Updated: Jul 2, 2026

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Food allergy: diagnosis, treatment, prognosis, and prevention
1Northwestern University Feinberg School of Medicine, USA. js-kim@childrensmemorial.org
Insights
Pediatric food allergy affects 6% of U.S. children. Diagnosis requires medical history and allergy testing, while management involves allergen avoidance and prompt epinephrine administration for unexpected reactions.
Area of Science:
- Pediatric Allergy and Immunology
- Clinical Medicine
Background:
- Food allergy impacts approximately 6% of children in the U.S., with many more presenting with concerns.
- Young children with atopic dermatitis are at a higher risk for developing food allergies.
Purpose of the Study:
- To provide guidance for primary care providers on diagnosing and managing suspected food allergic reactions in children.
- To emphasize the importance of accurate diagnosis and preparedness for managing food allergy.
Main Methods:
- Referral to an allergist for suspected food allergic reactions.
- Utilizing medical history and allergy testing (wheal size, sIgE concentration) for diagnosis.
- Patient and family education on allergen avoidance and emergency treatment.
Main Results:
- Stronger test responses generally correlate with clinical allergy, but must be interpreted with medical history.
- Allergen avoidance is the primary method for preventing reactions.
- Prompt intramuscular epinephrine administration is crucial for unexpected reactions.
Conclusions:
- Judicious application of allergy testing, considering medical history, is essential for accurate diagnosis.
- Current management relies on strict allergen avoidance and preparedness for emergency treatment.
- Ongoing education on epinephrine autoinjector use is vital for patient safety.
Abstract:
Primary care providers are advised to refer to an allergist those children in whom they suspect a food allergic reaction. Approximately 6% of U.S. children have food allergy, although many more parents will present with concerns of a food-induced condition. At higher risk are young children with atopic dermatitis. Generally, the stronger the test response (wheal size or sIgE concentration), the more likely there is to be clinical allergy. However, testing must be applied judiciously. Most importantly, the medical history must be considered in order to interpret test results appropriately. Avoidance of the offending food allergen is currently the only way to prevent reactions. Because exposures and reactions can occur unexpectedly, patients and their families must be prepared to treat symptoms quickly with intramuscular epinephrine in the lateral thigh. Hopefully, additional treatment options will become available in the near future to ease the anxiety and fearfulness that parents and patients face on a daily basis. Until then, healthcare providers are urged to demonstrate the correct administration of autoinjectable epinephrine using a placebo device and review the technique with families on an ongoing basis.
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