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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Related Experiment Video

Updated: Jul 2, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Does prostate cancer co-opt the developmental program?

Paul C Marker1

  • 1School of Pharmacy, Paul P. Carbone Comprehensive Cancer Center, Division of Pharmaceutical Sciences, University of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA. marker@wisc.edu

Differentiation; Research in Biological Diversity
|August 30, 2008
PubMed
Summary
This summary is machine-generated.

Cancer progression mirrors normal development, driven by stem cells. Prostate cancer hijacks developmental pathways, like androgen signaling, but with critical alterations, highlighting differences from normal tissue renewal.

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Area of Science:

  • Oncology
  • Developmental Biology
  • Molecular Urology

Background:

  • Cancer is hypothesized to mimic normal development and tissue renewal processes.
  • Both normal tissues and tumors rely on self-renewing stem cells and their proliferative progeny.
  • Tumors exhibit impaired differentiation, leading to an accumulation of undifferentiated, actively dividing cells.

Purpose of the Study:

  • To evaluate the validity of the cancer-as-caricature-of-development hypothesis in prostate cancer.
  • To investigate the role of stem cells and developmental pathways in prostate cancer progression.
  • To identify differences in developmental pathway regulation between normal prostate and prostate tumors.

Main Methods:

  • Review of descriptive studies on normal tissues and cancers.
  • Analysis of recent research on stem cell properties in prostate development and cancer.
  • Examination of gene expression and signaling pathway alterations in prostate cancer, focusing on the androgen-signaling pathway.

Main Results:

  • Stem cell-like properties are critical for both prostate development and cancer progression.
  • Genes regulating prostate development are re-expressed during prostate cancer.
  • The androgen-signaling pathway is significantly altered in prostate cancer through genetic and epigenetic changes, impacting its targets and transcriptional outcomes.

Conclusions:

  • The hypothesis that cancer caricatures normal development is supported by findings in prostate cancer.
  • Prostate cancer progression involves the dysregulation of developmental pathways, particularly androgen signaling, through unique molecular mechanisms.
  • Further research is needed to explore alterations in other developmental pathways during prostate cancer progression.